The Francis Crick Institute – London, United Kingdom
Chairs: Michael Andreeff, Dominique Bonnet, Daniela S. Krause, Simon Méndez-Ferrer
This workshop offers highest level science on the nature of the normal and malignant haemopoietic stem cell niche. It also aims to present strategies to target haematological cancers in their tumour microenvironment, thereby combining basic research efforts with possible clinical applications. It is designed to promote scientific interaction between participants from all over the world, involving junior and senior biologists and clinicians working in both the academic and industrial settings.
- Define the currently known complexities of the normal and malignant haematopoietic stem cell niche
- Define the complexities of metabolic changes in the bone marrow microenvironment in health and disease
- Define the effects of inflammatory processes on the bone marrow microenvironment in health and disease
- Define the interaction of haematological cancer cells with their microenvironment and methods to visualize and mimic these
- Define strategies to target the malignant haematopoietic stem cell niche to augment existing therapies